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Indian J Physiol Pharmacol ; 1976 Jul-Sep; 20(3): 172-6
Article in English | IMSEAR | ID: sea-107919

ABSTRACT

The effects of a new series of glutarimide compounds have been studied in acetylcholine induced auricular fibrillation in anaesthetized cats and epinephrine induced ventricular arrhythmmias in conscious pigeons. Some of the compounds showed varying degree of protective action against experimental arrhythmias. However these compounds were found to be less potent than quinidine. The mechanism of antiarrhythmic action has been discussed.


Subject(s)
Acetylcholine , Anesthesia, Local , Animals , Anti-Arrhythmia Agents/therapeutic use , Atrial Fibrillation/chemically induced , Cats , Columbidae , Epinephrine , Female , Guinea Pigs , Imides/therapeutic use , Male , Piperidines/therapeutic use , Piperidones/therapeutic use , Rabbits , Ventricular Fibrillation/chemically induced
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